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Clinical Therapeutics, 10 (5), 543-552

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This prevents bacterial growth during the weeks between reconstitution and complete use

This means: No human PK reference data No human bioavailability data No human metabolism or clearance data Rodent-to-human PK extrapolation is therefore speculative This is a major context for research framing

If your semaglutide was accidentally left in a hot car, freezer, or unrefrigerated environment beyond the 28-day window, discard it rather than risk reduced efficacy or potential safety issues