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Thiazolidinediones have been associated with a reduced risk of certain cancers, although concerns over their safety continue to be debated
Thyroid hyperplasia and neoplasm adverse events associated with GLP-1 receptor agonists in FDA adverse event reporting system
Notably, significant reductions of death from any causes were shown in both the LEADER trial with liraglutide (HR 0.85
Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity
Endocrine Practice , 27(3), 220225
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