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It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/-catenin signaling pathways were reported to be implicated in these protective effects

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Early-phase clinical trial data, including results from a Phase 2 trial published in the New England Journal of Medicine in 2023, demonstrated mean weight loss of up to approximately 24% of baseline body weight at 48 weeks in adults with obesity who did not have type 2 diabetes

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Each of these methods has its place, depending on your needs and lifestyle