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If a compounded product contains peptide fragments, impurities, aggregates, degradation products, or an incompletely characterised active ingredient, the immune system may recognise parts of that product as foreign

There is now tremendous interest in the heterogeneity of astrocytes across the CNS and there is an ongoing explosion of studies that are expanding and correlating information about structural, genetic and functional diversity of astrocytes across the healthy CNS

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Further, this pathology may be exacerbated by D2 downregulation, creating an inflammatory imbalance

An imbalance favoring quinolinic acid can drive excessive NMDA receptor stimulation, excitotoxicity, and oxidative stress, whereas reduced kynurenic acid may diminish protective modulation of glutamate transmission [277]

This premature breakdown can lead to the release of byproducts that irritate the stomach lining, leading to that "pain" or "heavy" feeling