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Prolonged daily dosing beyond 12 weeks transitions naturally into maintenance protocols using 23 doses weekly, which thousands of users sustain year-round without reported tolerance or receptor desensitization

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Acknowledgments The authors would like to acknowledge the use of generative AI technology, specifically Scholar AI, based on OpenAI's GPT-4 architecture, for revising the grammar of this paper

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Together, these actions reduce appetite and food intake, leading to weight loss in a majority of people who take the medications

Neuropharmacology 190 , 108511 (2021)