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In line with this finding, a different research discovered that changes in the SLC22A1 gene, responsible for OCT1, decreased the absorption of metformin in the liver without impacting the ability of metformin to lower glucose levels in individuals with T2DM (Zhou et al., 2009

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However, food-first approaches should always be prioritised where possible, with supplements serving as an adjunct rather than replacement for a balanced diet

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