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Additional information Peer review information Nature Chemical Biology thanks Dohoon Kim and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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The body preferentially uses -tocopherol, and only -tocopherol supplementation can reverse vitamin E deficiency symptoms

(10) M Backmund, K Meyer, H B Rothenhaeusler, and M Soyka (1998) Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial Journal of Clinical Psychopharmacology, 1998 Jun, Volume 18 (Issue 3), Pages 257-8

Therefore, we hypothesized that oral L-serine treatment could reprogram the transcriptomic and proteomic landscape of systemic immune cells, thereby modulating neuroimmune communication