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Dosage and timing may influence the occurrence of side effects

In contrast, less atherosclerosis prone endothelium is exposed to laminar shear stress causing activation of signaling pathways that maintain endothelial cell coaxial alignment, proliferation, (13,14) glycocalyx layer, (15) and survival (12,16)

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Fiorello CVDS

10.1007/s13311-018-0606-7

Under certain conditions, GGT-mediated degradation of GSH facilitates the formation of reactive oxygen species, causing lipid peroxidation of cell membranes, which ultimately leads to apoptosis or necrosis of gastric epithelial cells in vitro 15