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In this work, we rationally design biodegradable ZnFe 2 O 4 @Pt@PEG-GOx nanoparticles (ZFPG NPs) featuring five enzyme activities similar to POD, CAT, OXD, GOx, and glutathione oxidase (GSHOx) for magnetic targeting-enhanced and MRI-guided sono-metallo-immunotherapy, as illustrated in Fig

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