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High vitamin B12 levels are often seen as less concerning because they usually dont cause symptoms and are typically the sign of an underlying condition, not a direct health risk 2 , 5

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Most reactions resolve spontaneously upon continued use or dose adjustment

Clinically, I have seen that having the MTHFR variation doesnt necessarily mean one is destined for a lot of health challenges and symptoms, and having a greater number of variations doesnt always mean the person will have more symptoms