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Dysregulation of HDAC activity has been implicated in several diseases, such as cancer, neurodegenerative disorders, and metabolic disorders [261]

Next, we investigated the mechanism by which NFT triggered the activation of Nrf2 at the molecular level

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Table 3 Secondary outcomes of patients with a diagnosis of T2DM receiving SGLT2is versus GLP1-RAs Values are presented as the number of events per 1,000 person-years (95% confidence interval)

GLP-1 receptor agonists slow gastric motility, which can shift the time-to-peak (Tmax) of orally administered drugs