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FIN56 promotes GPX4 degradation while depleting coenzyme Q10, creating a dual node pressure on the lipid antioxidant network that can overcome single target resistance and broaden ferroptosis induction across resistant states (87, 88)

Oral is a reasonable option for patients who cannot or will not inject, but want systemic rather than purely local effect

Lipid hydroperoxide generation, turnover, and effector action in biological systems

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