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The review highlights FOXO4-DRI's unique mechanism as a peptide-based senolytic with high selectivity for senescent cells, while noting challenges for clinical translation including peptide delivery and stability

de Lamirande E, Gagnon C

Trial-Reported Endpoints by Phase Trial Lancet 2021 Phase 2 Duration 26 weeks Population Overweight/obese, no T2D (n=706) Mean Weight Loss 10.8% at 4.5 mg vs 3.0% placebo Trial Lancet 2023 Phase 2 Duration 32 weeks Population T2D + obesity (n=92) Mean Weight Loss 8.1% cagrilintide alone

It's particularly important for rapidly dividing cells, such as those in the gut lining and immune system

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Oxidative stress and regulation of glutathione in lung inflammation