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Additionally, efforts have been made to standardize and manage the quality control of Hymenoptera venom, including BV, to ensure its therapeutic efficacy (Oliveira Orsi et al., 2024)

Multimodal research is essential to bridge the translational gap and optimize therapeutic development pipelines

Klebsiella aerogenes, identified in some IBS patients' microbiota and carrying a histidine decarboxylase gene, is a major producer of histamine [57]

Studies report 75% reduction of lipid peroxidation in gastric mucosa homogenates

In comparison, direct NSP inhibitors have rapid onset but may require more frequent dosing and have limited inhibitory effects on high-concentration NSPs at inflammatory sites