While the enhanced permeability and retention (EPR) effect is commonly leveraged for tumor targeting, its variability in human tumors, unlike in consistent preclinical mouse models, poses a challenge for reliable drug delivery to cancerous tissues
Aardvark Therapeutics ARD-101 Aardvarks lead candidate, oral ARD-101 , is a potent pan-agonist of bitter taste receptors (TAS2R) that stimulates enteroendocrine cells in the digestive tract, triggering the release of gut-peptide hormones like GLP-1 and cholecystokinin (CCK), a satiety hormone that activates gut-brain signaling to regulate hunger
Apart from factors involved in the adaptation to acidic stomach conditions, many virulence factors produced by some H
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But demand for the drugs has exploded, with tens of millions now taking them worldwide
When I was doing research for this episode, I of course googled Lars Jrgensen