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It is a return to normal physiology

Do not start, stop, or change any medication without consulting your doctor

These side effects are usually mild to moderate and often decrease over time.

The results could lead to broader indications, further reinforcing its value in addressing chronic metabolic diseases

Conversely, in a randomized controlled trial involving adults with T2DM, administration of liraglutide for 26 weeks in addition to standard therapy with insulin, although significantly decreased body weight and levels of glycated hemoglobin HbA1c in patients, but at the same time failed to reduce Becks Depression Inventory (BDI) scores (de Witt 2014)

We propose that liver-targeted TR agonists that are capable of uncoupling beneficial effects from deleterious effects could be tested in future clinical studies for the treatment of type 2 diabetes