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Under physiological conditions, Nrf2 translocates from the cytoplasm to the nucleus upon oxidative challenge, binding to ARE sequences to induce expression of protective genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase catalytic subunit (GCLC) (Xu et al., 2023

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Found in virtually every cell of the body, glutathione helps protect against free radical damage

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Hg hazard added to the environment through volcanic eruption, fuels or raw materials of batteries, electric materials, sludges, fertilizers, lime, and manures (Figure 2) [28, 29]