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3 We now have 12 classes of glucose-lowering medications approved for the treatment of T2DM in the U.S

Dietary approaches that may enhance GLP-1 secretion include: Increase fiber intake : Consuming adequate dietary fiber daily (approximately 25g for women and 38g for men according to US Dietary Guidelines, though most Americans fall short) may promote GLP-1 release

This phenomenon, sometimes called tolerance or dose creep, is reported anecdotally with tirzepatide, though the clinical trial data does not show significant tolerance development at fixed doses over 72 weeks

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Traditionally, diagnosis has depended on invasive liver biopsy