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Researchers tracking how fast tirzepatide works typically observe rapid improvements in blood sugar even before significant weight loss occurs

In the Standards of Medical Care in Diabetes2021, the ADA recommend that for people with indications of high risk or established CKD either a sodium-glucose co-transporter-2 inhibitor (SGLT2i) or a glucagon-like peptide-1 receptor agonist (GLP-1 RA) be considered as a treatment option, independently of metformin use [15]

Because oral options sit directly within the stomach to be absorbed, some patients report a higher frequency of upper gastrointestinal symptoms, including acid reflux, indigestion, and localised stomach discomfort during the morning fasting window

Kim CS, Kim SW