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Overload of mitochondria with ammonium instigates over-production of reactive oxygen species and opening of mitochondrial permeability transition pore, which further damages astrocytes and induce astrocyte swelling

NADPH has the effect of eliminating reactive oxygen species (ROS) in the body, and IDH1 mutation weakens its ability to eliminate ROS

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Thus, This enables to express in terms of [ R ] ss : where with and The p , the ratio of Michaelis rates of dephosphorylation and phosphorylation defined in Eq

Scientific databases such as PubChem may also provide compound-level reference information

It is simply the safer one.