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Moreover, IBD patients exhibited lower prevalence of nausea, vomiting, and diarrhea, but increased rates of constipation (11%) in comparison to the general population (103)

It should not be surprising that most of the side effects are related to the mechanism of actions and can be somewhat predicted by the anatomical location of the GLP-1 receptors

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EVOO polyphenolsincluding oleuropein, oleocanthal, and hydroxytyrosolhave been shown to: Inhibits DPP-IV activity, helps to preserve GLP-1 and other hormonal signals, and extends its metabolic benefits

Andres Acosta, a gastroenterologist at the Mayo Clinic, said the findings tell us that GLP-1 medications are generally safe but may carry a risk of serious gastrointestinal side effects

Cancer Res 63 : 36373645