Two new classes of agents are being developed to take advantage of the unique glucoregulatory potential of GLP-1: The incretin mimetics, such as exenatide (synthetic exendin-4, a peptide resistant to proteolytic cleavage by DPP-IV) or derivatives of GLP-1 (created by chemical modification of the native hormone, to render them resistant to rapid proteolytic cleavage by DPP-IV), targeting the pharmacological effects, and insufficient secretion of GLP-1 seen in type 2 diabetes
Semaglutide requires a gradual dose escalation over 16 to 20 weeks to minimize side effects
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According to NICE guidance (NG28) , GLP-1 agonists are recommended for type 2 diabetes when metformin and other treatments have not achieved adequate control
GLP-1 costs & strategies