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TGF- pathway activation occurs with upregulation of TGF- superfamily genes for tissue repair, while simultaneously suppressing pathological TGF-1 secretion in fibrotic conditions

May increase slightly with age due to declining pituitary response

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This appetite-suppressing effect is graduated based on dose and in clinical trials for semaglutide and tirzepatide, participants experienced statistically significant weight loss and reduced energy intake even during the early, lower-dose titration period