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doi: 10.1007/s00253-016-8032-4 23 KnezevicJStarchlCTmava BerishaAAmreinK

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You should seek medical advice if you notice: Severe or persistent symptoms that do not improve with time or simple changes to diet and habits Signs of dehydration such as very dark urine, dizziness or not passing urine for many hours Symptoms that worsen rather than settle after a few days Trust your instincts

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Subsequently, the physician advises an appropriate lifestyle intervention

Fagher, B., Cederblad, G., Eriksson, M., Monti, M., Moritz, U., Nilsson-Ehle, P., and Thysell, H