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The restoration of first-phase insulin response is a well-established observation caused by weight loss in type 2 diabetes [29]

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But oral medication does not remove the need for medical supervision

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4.5 Impact of SGLT-2 inhibitors and GLP-1 receptor agonists on kidney function Multiple clinical trials have demonstrated the renoprotective effects of SGLT-2i and GLP-1 RAs in patients with T2DM and CKD