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In addition, combination of ganitumab with metformin is being tested in an ongoing I-SPY2 trial, which aims to identify most effective agents to treat various types of breast cancer and learn about the predictors of treatment response [155]

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Human and Animal Rights and Informed Consent All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards and international/national/institutional guidelines)

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