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The patients in this editions column demonstrate the relevance of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in the realm of neuro-ophthalmic disease

J Clin Invest 1984 Mar

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Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]