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10.1016/j.eclinm.2020.100458 60 El-KenawiA

In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

According to Celltrion, Steqeyma was approved based in part on the findings of a Phase III study in plaque psoriasis, which demonstrated that the biosimilar had no clinically meaningful differences versus Stelara in terms of efficacy or safety

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PMID: 28340339 Chondrocyte senolysis study

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