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Mice with high Fgf21 levels display reduced sugar intake when given the free choice between a regular diet and a diet enriched in sucrose compared to those with lower circulating Fgf21 [116]

Sustained weight loss with semaglutide once-weekly treatment as add-on to standard of care in overweight or obese subjects: A phase 3a trial

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Interestingly, the study suggests that GHK-Cu might stimulate the secretion of TIMP-1 and TIMP-2, which are specific inhibitors of metalloproteinases, indicating a role in finely tuning the balance of matrix remodeling