He reports no personal equity in companies manufacturing tirzepatide
Although a recent clinical trial investigating IMC-A12 and cetuximab in colorectal cancer patients did not show a benefit with IGF-1R inhibition [60], study patients were resistant to prior anti-EGFR therapy and staining for activated AKT, a marker of EGFR and IGF-1R signaling, did not correlate with outcome
Common medications include methimazole and propylthiouracil, which help reduce the production of thyroid hormones
In a response to questions about Pfizer ending the trial of its oral drug, a company spokesperson pointed Scientific American to the press release that announced that decision and said Pfizer is working on other early-stage oral drug candidates for weight loss, including one that works on a similar hormone to GLP-1 that is currently in phase 2 clinical trials
Biochim Biophys Acta Proteins Proteom 1867(10):890908
These may not yet have achieved an equivalent scale of impact compared to GLP-1s, but some have not been tried at scale or with the intensity that is required, but may offer more cost-effective, long lasting or equitable solutions [11]
