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Our data clearly showed that KL1 had no effect on oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) (Extended Data Fig

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Absence of hydroxyurea-induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia

Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)

Adding to the complexity, an exogenous agent may be causative (like the TB bacillus) or simply additive, exacerbating an inflammatory response to some other unrelated underlying insult (Ma et al., 2023)

Allergic Reactions: Rare, but some individuals may experience allergic responses