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doi: 10.3389/fnut.2025.1686056 Received 14 August 2025 Accepted 25 September 2025 Published 16 October 2025 Volume 12 - 2025 Edited by Mingyue Song, South China Agricultural University, China Reviewed by Ludovica Verde, University of Naples Federico II, Italy Arely Vergara-Castaeda, La Salle University of Northwest, Mexico Updates Copyright 2025 Chyliska and Maciejczyk

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In patients with a homozygous inactivating mutation of the GHRH receptor, intravenous hexarelin produced a complete absence of GH response plasma GH stayed under 1 ng/mL, a 50- to 100-fold deviation from the normal response while prolactin, ACTH and cortisol responses to hexarelin were normal [6]

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Our study adds to the growing body of research on the role of basal GLP-1 level where higher level of GLP-1 at fasting state mediates greater treatment response to DPP-IV inhibitor