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The histological assessment used to investigate the healing parameters of the mice included edema, formation of blood vessels, retained follicles, formation of reticulin and collagen, number of inflammatory cells, and the number of subjects experiencing complete re-epithelialization

Some residual tenderness with direct pressure may persist

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In monotherapy clinical trials of topiramate 50 to 200 mg/day for the prophylaxis of migraines, the following CNS effects occurred more frequently with topiramate than placebo: paresthesias (35% to 51% vs