Everything needs to be in balance.[ref][ref] Prostate cancer risk is increased with 4-HOE1(E2) metabolites also.[ref] In general, the estrogen metabolites that start with 2 are good, and the ones that start with 4 or 16 need to be limited or at least eliminated quickly from the body.[ref] Here is a diagram of how these metabolites go together: As you can see, upregulating the CYP1A1 enzyme is going to increase the 2-OHE1 path
In animal models of hind limb ischemia, the peptide accelerates blood flow recovery and increases vessel number, confirming functional angiogenic capacity
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doi:10.1016/j.biochi.2016.02.012 [PubMed] [Elsevier] 119
W., Perkins, C., Jones-Leone, A., Yang, F., Perry, C., & Lingvay, I
