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Lilly's Zepbound demonstrated significantly greater weight reduction compared to Novo Nordisk's Wegovy in SURMOUNT-5 head-to-head trial

Heart Disease Risk Assessment: For those with a history of heart disease, careful monitoring is essential

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All medications are started at the lowest dose and increased to achieve the best results with the lowest side effects

Weekly semaglutide injections (up to 2.4mg) are more convenient and typically lead to 1015% reductions (STEP trials)

Injection Site Issues Repeatedly injecting into the same site can cause localized lipodystrophy, where subcutaneous tissue becomes scarred and absorption becomes irregular