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3.1 VDRs and distribution Active form of vitamin D, 1,25-dihydroxyvitamin D (calcitriol), can cross the bloodbrain barrier and interact with vitamin D receptors (VDRs), which are found in brain areas involved in cognition, including the hippocampus, prefrontal cortex, amygdala, and thalamus (68)

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These letters appear to be indiscriminate cost saving initiatives and are being sent out as individual practice directives and not that of the CCG (Clinical Commissioning Group)

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