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Description

Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022)

The critical factor is that loading usually takes at least 2-3 months, so this is best timed to coincide with the start of serious building in training load towards a goal

Persistent issues beyond 3 months warrant dose adjustment or medical review

Litwiniuk A, Baranowska-Bik A, Domanska A, Kalisz M, Bik W