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As well as cAMP production, dynamin ablation reduces ERK phosphorylation (Fletcher et al., 2018) and a strategy to prolong endosomal residence of exendin4 by covalent linkage to the SNAPGLP1 receptor led to prolongation of intracellular Ca 2+ responses in MIN6B1 beta cells (Podewin et al., 2018)

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Glucagon stimulates the release of glucose from glycogen stores (95, 96)

Notably, britanin (Bri), a sesquiterpene lactone extracted from Inula japonica, also reduces AMPK phosphorylation, downregulates SREBP1c expression, and alleviates hepatic oxidative stress and apoptosis by decreasing Caspase3 expression and the Bax/Bcl2 ratio, thereby mitigating NAFLD (Dou et al., 2024)

DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis