In the advancement of treatment strategies, although approaches like mitochondria-targeted antioxidants (e.g., MitoQ) and macrophage metabolic reprogramming (e.g., SDH inhibitors) have shown significant efficacy in animal models, their clinical translation faces severe challenges in targeted delivery and microenvironment adaptation
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6.4.5 Neuroprotective agents Pharmacological agents that promote neuronal survival and protect against neuroinflammation, such as antioxidants or specific enzyme inhibitors (e.g., COX-2 inhibitors), may also hold therapeutic potential (Choi et al., 2010)
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The specific roles of jak/stat signaling pathway in sepsis
10.1038/s41586-019-1170-y Nature 157 WangY.WangG.TanX.KeK.ZhaoB.ChengN.et al (2019e)