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SUSTAIN FORTE: Ozempic injection 1 mg vs 2 mg 1,4 Study design: 40-week, randomized, active-controlled, parallel-group, double-blind, phase 3B efficacy and safety trial of Ozempic injection 2 mg vs Ozempic injection 1 mg in patients with T2D in need of treatment intensification

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Dose from 1 mg to 20 mg is found suitable if sufficient sustained action and sufficient amount of penetration enhancers are employed

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This indicates that the upper adenosyl ligand is required for optical coupling and cleavage of the upper axial C-Co bond