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GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

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In 1990 Mojsov and colleagues also described the existence of a second biologically active form of GLP-1, labelled GLP-1 (7-36) amide, in the intestines (Mojsov, Kopczynski, Habener)

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