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It is also hypothesized that this leads to less glutamate available to produce aspartate, another excitatory neurotransmitter in the brain (Yudkoff et al., 2008)

Moreover, pain caused by nerve damage and inflammation resulting from diabetes or chemotherapy significantly enhance mitochondrial fission frequency 13,14,15

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[2] Goldstein AL, Hannappel E, Kleinman HK

Furthermore, abnormal lipid metabolism, marked by increased free fatty acid levels, exacerbates insulin resistance by disrupting insulin-mediated glucose metabolism in cells

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