The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized
Preventive cardiology is not separate from brain health
Patients typically begin using GLP with a lower dose that is gradually increased over several weeks, which helps minimize the onset of any potential side effects and helps the body to adjust to the medication
VSMC prolif.: vascular smooth muscle cell proliferation
Psychopharmacology 240 , 13731386 (2023)
These advancements position microneedle technology as a transformative approach for delivering GLP-1 receptor agonists, offering the potential to improve therapeutic adherence, minimize systemic side effects, and support decentralized care models for diabetes management [43]