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Res 25 , 15891597 (2007)

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Goal: Maintain testicular volume and function during TRT Approach: HCG 500 IU subcutaneously every other day (3x weekly) Begin same time as testosterone therapy Continue for duration of TRT Monitoring: Baseline testosterone, estradiol, LH, FSH Recheck at 6 weeks, then quarterly Adjust based on estrogen response Expected results: Maintained testicular size Preserved fertility potential Possible slight testosterone boost above TRT alone Protocol for fertility restoration on TRT Men on TRT who want to conceive face a decision

The peptide works anyway because GHK-CU is remarkably forgiving

BioRender ( was used to create the Fig

Epitalon's chromatin remodeling effect demonstrated in Khavinson's 2003 work on heterochromatin activation in aged cells removes structural barriers to gene expression that would otherwise limit GHK-Cu's transcriptional effects.11 Epitalon opens the chromatin