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Methods Study design The SEMPA trial (Effect of Empagliflozin and Semaglutide on Cardio-Renal Target Organ Damage in Patients with Type 2 Diabetes A Randomized Trial) was a 32 week investigator-initiated, randomised, partly placebo-controlled, partly open-label trial, designed to assess the separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and arterial stiffness as two co-primary outcomes

Later, it was reported that extraction using acetone will yield higher allicin compared to ethanol (Canizares et al., 2004a)

Insulin Degludec SURPASS-3 [9] is a phase 3 study, with an inclusion criterion of age greater than 18 years, a baseline HbA1c of 7.0-10.5%, BMI of at least 25 kg/m2, and participants who were insulin-naive and treated with metformin alone or in combination with an SGLT-2 inhibitor for at least three months before screening

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Studies with Semaglutide have shown that up to 40% of weight lost can come from lean tissue