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Several medications have entered phase 2 or 3 of clinical trials for PWS patients ( and this therapeutic approach of appetite modulation via the hypothalamus could provide promising results not only in PWS patients, but also for patients with other types of hypothalamic obesity

Dani SS, Makwana B, Khadke S, Kumar A, Jhund P, Nasir K, Sattar N, Al-Kindi S, Fonarow G, Butler J, Bhatt DL, Kosiborod MN, Nohria A, Ganatra S (2025) An observational study of cardiovascular outcomes of tirzepatide vs glucagon-like peptide-1 receptor agonists

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and is Director of Global Clinical Trial Partners