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These investigations have examined the compound's biochemical effects in cultured cells and animal models as part of broader research into NNMT and cellular metabolism Importantly, these findings relate to preclinical research and should not be interpreted as evidence of established clinical efficacy, safety or therapeutic benefit in humans

Potential Benefits: Significant Weight Loss: When combined with GLP-1 therapy, Cagrilintide has led to greater reductions in body weight than GLP-1s alone in clinical trials

H., Carney, M

Depot-selective lipolysis: The GH/IGF-1 signaling axis preferentially targets visceral adipose depots, promoting triglyceride hydrolysis and reduced VAT without significantly affecting subcutaneous fat or lean mass 1,3

Straight on, at eye level, reading the bottom of the meniscus

Peer Review All reports in the Ontario Health Technology Assessment Series are subject to external expert peer review