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GPX4: The core downstream antioxidant of system X c /GSH/GPX4 axis As the cornerstone of antioxidant defense, GPX4, a phospholipid peroxidation inhibitor, is the only glutathione peroxidase used for intracellular lipid peroxide reduction (Ursini et al., 1982)

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78,79 Manipulation of the hepcidin pathway is the current therapeutic approach in NTDT, which mainly focuses on rescuing the suppressed hepcidin expression induced by impaired erythropoiesis

Bo W, Tang J, Ma J, Gong Y