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If an individual in mid-life has a pro-neurodegenerative microbiome signature (low diversity, low SCFA-producers, high pro-inflammatory taxa), they might be counseled to intervene early via diet, prebiotics, or even prophylactic probiotics to shift their microbiome to a healthier state

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For laboratories, this subtype diversity is valuable because it enables structured experiments that map how a ligand behaves across a defined receptor landscape rather than assuming a single receptor state

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Brigelius-Flohe and Flohe, 2017