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subsequently, 5 L of 1 M iodoacetamide was added and incubated for 1 h, at room temperature and protected from light

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Group 2 was treated with HA, at a molecular weight of 3.010 Da and a concentration of 10 mg/mL, delivering a dose of 6 mg per injection

The stratum corneum showed a 2-hour lag, while the full epidermis required up to 7 hours for significant penetration

No large-scale Phase III clinical trials have been completed in humans, and long-term safety data in human subjects is lacking